团队名称：热带特色功能性植物种质创新与技术服务团队

团队研究方向：南药植物、热带油茶等的种质创新与开发利用

团队负责人：

吴友根，博士，三级教授，博士生导师。海南省领军人才、教育部宝钢优秀教师、南海名家、海南省高等学校优秀中青年骨干教师、海南省“515人才工程”第二层次人才、永利集团第四届“十佳教师”、永利集团教学名师。荣获中国侨联第九届“侨届贡献奖”、全国教学创新大赛三等奖、海南省教学创新大赛一等奖、永利集团教学创新大赛一等奖，合作获得海南省教学成果一等奖2项。先后主持国家自然科学基金5项、中央财政林业科技推广示范项目、海南省重点研发计划项目、海南省中药现代化专项资金项目等课题20多项目。在国内外核心刊物发表论文100多篇，主编著作5部、参编国家级规划等教材6部。申请国家发明专利5项，授权4项。参与选育品种6个，制定标准和规程6项，开发科技产品5个。

团队研究成果：

代表性论文：

1. Yan WP, Cao SJ, Wu YG*, Ye ZC, Zhang C, Yao GL, Yu J, Yang DM, Zhang JF. Integrated analysis of physiological, mRNA sequencing, and miRNA sequencing data reveals a specific mechanism for the response to continuous cropping obstacles inPogostemon cablin roots[J]. Frontiers in Plant Science, 2022, 13: 853110.

2. Lu Feng, Jian Chen,Wuping Yan, Zhouchen Ye, Jing Yu, Guanglong Yao*, YougenWu*, Junfeng Zhang, Dongmei Yang. Preparation of Active Peptides fromCamellia vietnamensis and their metabolic effects in alcohol-induced liver injury cells [J]. Molecules, 2022, 27, 1790.

3. Ming-Yang Chen, Fan-Dong Kong, Li Yang, Qing-Yun Ma, Qing-Yi Xie, Jing Yu, Peng-Wei Chen, Li-Man Zhou, You-Gen Wu*, Hao-Fu Dai*, You-Xing Zhao*. Phenethoxy Derivatives with Anti-inflammatory Activities from the Betelnut EndophyticTrichoderma asperellum G10 [J]. Journal of Naturnal Products, 2022.

4. Heqin Yan, Wei Zheng, Yong Wang, Yougen Wu, Jing Yu*, Pengguo Xia*. Integrative Metabolome and Transcriptome Analysis Reveals the Regulatory Network of Flavonoid Biosynthesis in Response to MeJA in Camellia vietnamensis Huang[J], Int. J. Mol. Sci. 2022, 23, 9370.

5. Zhouchen Ye, Jing Yu, Wuping Yan, Junfeng Zhang, Dongmei Yang, Guanglong Yao, Zijin Liu, Yougen Wu* and Xilin Hou*. Integrative iTRAQ-based proteomic and transcriptomic analysis reveals the accumulation patterns of key metabolites associated with oil quality during seed ripening ofCamellia oleifera [J]. Horticulture Research, 2021, 8: 157-183.

6. Guanglong Yao, Xuemei Tang, Zhouchen Ye, Wuping Yan, Jing Yu, Yougen Wu*, Junfeng Zhang, Dongmei Yang. Protective effect ofCamellia vietnamensis active peptide on alcohol-induced hepatocyte injury [J]. Food and Agricultural Immunology, 2021, 32(1), 425–449.

7. Wuping Yan, Zhouchen Ye, Shijia Cao, Guanglong Yao, Jing Yu, Dongmei Yang, Ping Chen, Junfeng Zhang*, Yougen Wu*. Transcriptome analysis of twoPogostemon cablin chemotypes reveals genes related to patchouli alcohol biosynthesis [J]. Peer J 9:e12025.

8. Lin Wang, Qing Yun Ma, Fan Dong Kong,Qing Yi Xie, Li Man Zhou, Haofu Dai,Rainer Kalscheuer, You Gen Wu*, You Xing Zhao*. Chemical constituents and nematocidal activity of the fruiting body ofRamaria stricta [J]. Chemistry of Natural Compounds, 2021, 57(4), 720-723.

9. Wuping Yan, Yuzhang Yang, Yougen Wu*,Jing Yu, Junfeng Zhang, Dongmei Yang, Zeeshan Ul Haq Muhammad. Isopentenyl Diphosphate Isomerase (IPI) Gene Silencing Negatively Afects Patchouli Alcohol Biosynthesis inPogostemon cablin[J]. Plant Molecular Biology Reporter, 2021, 39, 1-9.

10. Jiaocen Guo, Fandong Kong, Qingyun Ma, Qingyi Xie, Renshuai Zhang, Haofu Dai, YouGen Wu*, Youxing Zhao*. Meroterpenoids With Protein Tyrosine Phosphatase 1B Inhibitory Activities From the Fruiting Bodies ofGanoderma ahmadii [J]. Frontiers in chemistry, 2020, 8: 279.

11. Fan-Dong Kong, Tian-Feng Yi, Qing-Yun Ma, Qing-Yi Xie, Li-Man Zhou, Jin-Ping Chen, Hao-Fu Dai, You-Gen Wu*, You-Xing Zhao*. Biphenyl metabolites from the patchouli endophytic fungusAlternaria sp. PfuH1 [J]. Fitoterapia, 2020, 146, 104708.

12. Zhouchen Ye, YouGen Wu*, Zeeshan Ul Haq Muhammad, Wuping Yan, Jing Yu, Junfeng Zhang, Guanglong Yao, Xinwen Hu. Complementary transcriptome and proteome profiling in the mature seeds ofCamellia oleifera from Hainan Island [J]. Plos one, 2020, 15(2): e0226888.

13. Mingyang Chen, Qingyi Xie, Fandong Kong, Qingyun Ma, Liman Zhou, Jingzhe Yuan, Haofu Dai, Yougen Wu*, Youxing Zhao*. Two new indole-diterpenoids from the marine-derived fungus Penicillium sp. KFD28 [J]. Journal of Asian Natural Products Research 2020: 1-8.

14. Jiaocen Guo, Qingyun Ma, Fangdong Kong, Qingyi Xie, Liman Zhou, Qiong Ding, YouGen Wu*, Youxing Zhao*. Meroterpenoids from the Fruiting Bodies of Ganoderma ahmadii Steyaret and Their Protein Tyrosine Phosphatase 1B Inhibitory Activities [J]. Chinese Journal of Organic Chemistry, 2019, 39(11), 3264-3268.

15. Guang-Long Yao, Wei He, You-Gen Wu*, Jian Chen, Xin-Wen Hu, Jing Yu. Structure and functional properties of protein from defattedCamellia oleifera seed cake: Effect of hydrogen peroxide decolorization [J]. International Journal of Food Properties, 2019, 22(1), 1283-1295.

16. Guixiang Zhang, Yougen Wu*, Zeeshan Ul Haq Muhammad, Yuzhang Yang, Jing Yu, Junfeng Zhang, Dongmei Yang cDNA cloning, prokaryotic expression and functional analysis of 3-hydroxy3-methylglutaryl coenzyme A reductase (HMGCR) inPogostemon cablin[J]. Protein Expression and Purification, 2019, 163: 105454.

发明专利：

1.吴友根等. PcFPS基因的引物对及利用该引物对扩增的基因在提高广藿香百秋李醇中的应用，专利号：ZL 201811398321.6。

2.吴友根等.一种诺丽内生真菌的分离鉴定方法，专利号：ZL 201710657484.0。

3.吴友根等.一种去粉刺、去痘广藿香精油手工皂及其制作方法，专利号：ZL 201410014761.2。

4.吴友根等.一种广藿香快速生根育苗的方法，专利号：ZL 201410039484.0。

科技获奖：

1.广藿香等海南热带特色植物品种选育、活性成分研究及应用，获海南省科技进步二等奖（排名第一），2022年8月。

2.广藿香种质资源评价及主要活性成分形成的遗传机制研究，获海南省科技进步二等奖（排名第一），2014年12月。

3.广藿香种质资源微观结构、化学表征及遗传多样性的研究，获第四届海南省高等学校优秀科研成果二等奖（排名第一），2013年12月。